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Promethazine blocks the effects of a natural chemical called acetylcholine. This can help dry up a cough or runny nose, but can also cause side effects such as a dry mouth and dry nose. Some cough and cold remedies claim to suppress your cough or stop you bringing up phlegm.

This is because there's little evidence that they're any more effective than simple home remedies and they're not suitable for everyone. Promethazine will start to make you feel sleepy around 20 minutes after you take it and may work for up to 12 hours. If you're taking it for a cough or cold, allergies or feeling sick nausea , your symptoms should start to improve within 20 minutes.

The medicine should work for around 4 to 6 hours. Only take promethazine for a short time, unless your doctor says it's OK for you to take it for longer. Speak to your pharmacist or doctor before taking promethazine for longer than the medicine leaflet recommends. It's unlikely that you'll get addicted to promethazine. But it's best that you only take it for a very short time, unless your doctor tells you to take it for longer.

If you have bought a medicine containing promethazine, do not take it for longer than recommended on the packet without speaking to your pharmacist or doctor first. If you have taken promethazine for a long time and suddenly stop taking it, it's possible you might feel dizzy, sweaty or sick, have a racing heart and have trouble sleeping. Speak to your doctor if you have taken promethazine for a long time and want to stop taking it.

Promethazine is known as a drowsy sedating antihistamine as it makes you sleepy. Non-drowsy antihistamines are less likely to have this effect. These include cetirizine , fexofenadine and loratadine. Most people prefer to take a non-drowsy antihistamine as it's less likely to interfere with their everyday routine. You might choose to take a drowsy antihistamine, however, if you're having problems falling asleep, or if symptoms like itching or coughing are keeping you awake.

There is not enough information available to say whether one antihistamine is better than another for treating allergies. You may need to try a few different medicines to find what works best for you. Ask your pharmacist or doctor for advice if you're unsure. You can take 2 different antihistamines at a time, if your doctor says it's OK.

If you have a severe itchy skin rash, your doctor may recommend 2 different antihistamines together for a few days. You could take a non-drowsy antihistamine such as cetirizine , fexofenadine or loratadine during the day, and a drowsy antihistamine at night if itching is making it difficult to sleep. Do not take another drowsy antihistamine together with promethazine. It'll make you very tired and sleepy.

Other drowsy antihistamines include chlorphenamine Piriton and diphenhydramine Nytol Original. Do not take 2 antihistamines together unless you have been advised to by your doctor. If you take it for insomnia or take it at bedtime, promethazine will help you sleep. If you take it during the day for other conditions, such as allergies, it might make you feel sleepy during the day as well. Yes, you can take promethazine together with some painkillers, such as paracetamol or ibuprofen.

If you take promethazine with painkillers that contain codeine such as co-codamol or other prescription painkillers , you may feel very tired and sleepy. It's important to check the packaging or label of your medicine carefully.

This is because some promethazine products already contain a painkiller. Do not take extra painkillers if this is the case, as there's a risk of overdose. Speak to your pharmacist if you're not sure whether a medicine already contains a painkiller. Do not drive a car or ride a bike if promethazine makes you sleepy during the daytime, gives you blurred vision or makes you feel dizzy, clumsy or unable to concentrate or make decisions.

This may be more likely when you first start taking promethazine, but could happen at any time for example, when starting another medicine. It's an offence to drive a car if your ability to drive safely is affected. It's your responsibility to decide if it's safe to drive. If you're in any doubt, do not drive. Talk to your doctor or pharmacist if you're unsure whether it's safe for you to drive while taking promethazine.

UK has more information on the law on drugs and driving. There's no evidence to suggest that taking promethazine reduces fertility in either men or women. But speak to a pharmacist or doctor before taking it if you're trying to get pregnant. Promethazine does not affect any type of contraception, including the combined pill and emergency contraception. You will not be able to breathe properly and may have difficulty waking up. However, do not drink alcohol.

And if you take promethazine to help you sleep, try not to have drinks that contain caffeine, like coffee, tea, cola or energy drinks. Caffeine has the opposite effect to promethazine and can stop the medicine working. Yes, it's dangerous to take promethazine with recreational drugs.

This is because it can slow or stop your heart and lungs. Mixing promethazine and codeine in large amounts slows down the central nervous system brain and spinal cord , which can slow breathing and heart rate. It's even more dangerous when taken with alcohol or other drugs and has caused people to die.

Find out more the side effects of some recreational drugs on the Frank website. Promethazine will only help you sleep while you're taking it, so there are a number of things you can do instead to help yourself have a good night's sleep :. If you have hay fever , it helps if you do not spend too much time outside if the pollen count is high.

The best way to prevent any sort of allergic reaction is to avoid the substance that you're allergic to, if you can. There are some practical steps you can follow to help prevent allergies. Page last reviewed: 27 October Next review due: 27 October Promethazine Phenergan - Other brand names: Avomine, Sominex On this page About promethazine Key facts Who can and cannot take promethazine How and when to take promethazine Side effects How to cope with side effects of promethazine Pregnancy and breastfeeding Cautions with other medicines Common questions about promethazine.

About promethazine Promethazine is an antihistamine medicine that relieves the symptoms of allergies. Promethazine is used for: short-term sleep problems insomnia — including when a cough, cold or itching is keeping you awake at night allergies, including hay fever and hives urticaria feeling and being sick vomiting — due to motion sickness or vertigo cold symptoms, such as coughing and a runny nose You can buy promethazine from pharmacies, where it's often sold as Avomine, Phenergan or Sominex.

It comes as tablets, capsules and a liquid that you swallow. Do not drink alcohol while taking promethazine. Alcohol increases the risks of side effects. To help you sleep, take promethazine 20 minutes before you go to bed. It normally takes about 30 minutes to work. To prevent motion sickness, take promethazine the night before a long journey or 1 to 2 hours before a short journey. Common side effects of promethazine include drowsiness, headaches, nightmares and feeling dizzy, restless or confused.

Promethazine can be taken by most adults. To make sure it's safe for you, tell your doctor or pharmacist if you: have ever had an allergic reaction to promethazine or any other medicine have an eye problem called primary angle closure glaucoma have problems peeing or emptying your bladder have epilepsy or any other health problem that causes seizures or fits are due to have an allergy test. Promethazine can affect your results, so you may need to stop taking it a few days before your test.

Ask the clinic where you are due to have your allergy test are unable to have any alcohol — some liquid promethazine products contain a very small amount of alcohol, so check the ingredients and the packaging carefully are trying to get pregnant. Promethazine can affect home pregnancy tests. If you think you're pregnant, speak to your doctor so they can arrange a blood test instead.

Important If you have bought promethazine or any medicine containing promethazine from a pharmacy, follow the instructions that come with it, or ask a pharmacist for advice. Dosage and strength Promethazine comes in 10mg, 20mg and 25mg tablets. Your dose depends on why you're taking it: short-term insomnia — you'll usually take 20mg to 50mg at night hay fever — you'll usually take from 10mg twice a day to 20mg, 3 times a day hives — you'll usually take from 10mg twice a day to 20mg 3 times a day preventing motion sickness — you'll usually take 25mg 1 to 2 hours before a short journey or 25mg the night before a long journey treating motion sickness — take 25mg as soon as possible and 25mg the same evening, followed by 25mg the following evening if you need it vertigo — the dose can vary from 25mg a day to 25mg 4 times a day If you're taking liquid which contains 5mg of promethazine in 5ml, follow the instructions that come with the medicine for how much to take.

Promethazine mixed with other medicines Promethazine can come mixed with other medicines, such as paracetamol. How to take it You can take promethazine tablets, capsules and liquid with or without food. How to take tablets and capsules Always take your promethazine tablets or capsules with a drink of water. How to take liquid Liquid medicines containing promethazine come with a plastic syringe or spoon to help you measure out the right dose.

What if I forget to take it? For motion sickness, take it as soon as you remember. What if I take too much? Too much promethazine can be dangerous. If you take more than your usual dose, you may: feel very sleepy have a very fast, irregular or pounding heartbeat palpitations have breathing problems In serious cases, you can become unconscious or have seizures or fits and may need emergency treatment in hospital.

If your child takes too much promethazine, they may also: move unsteadily or stumble have uncontrolled movements, especially in their hands or feet see or hear things that are not there hallucinations have an irregular heartbeat. Urgent advice: Contact for advice if:. Common side effects Like all medicines, promethazine can cause side effects, although not everyone gets them.

Talk to your pharmacist or doctor if these side effects bother you or do not go away: feeling tired during the daytime nightmares feeling dizzy or unsteady on your feet, or having difficulty concentrating headaches Promethazine can sometimes make your skin more sensitive to sunlight. If you're over 65, you're more likely to get side effects such as: feeling confused dry mouth blurred vision difficulty peeing Talk to a doctor or call straight away if you have these side effects.

Serious side effects Call your doctor straight away if: the whites of your eyes or your skin turn yellow, although this may be less obvious on black or brown skin — these can be signs of liver problems you notice more bruising or bleeding than normal you have muscle stiffness or shaking, or unusual face or tongue movements Serious allergic reaction In rare cases, it's possible to have a serious allergic reaction anaphylaxis to promethazine.

Information: You can report any suspected side effect using the Yellow Card safety scheme. Visit Yellow Card for further information. What to do about: feeling sleepy during the daytime — this usually wears off 12 hours after a dose. Do not drive, cycle or use tools or machinery if you're feeling this way. If the feeling does not go away or is troubling you, do not take any more medicine and speak to a pharmacist or doctor.

Promethazine and pregnancy Promethazine can be used in pregnancy. Promethazine and breastfeeding If your doctor or health visitor says your baby is healthy, promethazine can be used during breastfeeding. Non-urgent advice: Tell your doctor if you're:. Tell your pharmacist or doctor if you're taking: a type of antidepressant called a monoamine oxidase inhibitor, such as phenelzine a type of painkiller called an opioid, such as codeine , morphine or oxycodone any medicine that makes you drowsy, gives you a dry mouth, or makes it difficult for you to pee — taking promethazine might make these side effects worse If you're taking a cough or cold remedy or a painkiller containing promethazine, check carefully what the other ingredients are.

Mixing promethazine with herbal remedies and supplements There might be a problem taking some herbal remedies and supplements alongside promethazine, especially ones that cause side effects such as sleepiness, a dry mouth or making it difficult to pee.

Ask your pharmacist for advice. Important: Medicine safety Tell your doctor or pharmacist if you're taking any other medicines, including herbal medicines, vitamins or supplements. ERJ Open Res ; Nadel JA. Mucous hypersecretion and relationship to cough. Pulm Pharmacol Ther; Efficacy of brompheniramine maleate for the treatment of rhinovirus colds.

Clin Infect Dis ; ERS guidelines on the assessment of cough. Evaluation of antitussive agents in man. Pulm Pharmacol ; Codeine intoxication associated with ultrarapid CYP2D6 metabolism. N Engl J Med ; Antitussive drugs— past, present, and future. Pharmacol Rev ; Lack of effect of codeine in the treatment of cough associated with acute upper respiratory tract infection.

J Clin Pharm Thei ; Assessment of the antitussive efficacy of codeine using cough sound pressure levels as a means of measuring cough. European Medicines Agency. Codeine not to be used in children below 12 years for cough and cold. FDA evaluating the potential risks of using codeine cough-and-cold medicines in children. Application and validation of a computerized cough acquisition system for objective monitoring of acute cough: a meta-analysis.

Chest ; A randomized placebo controlled trial to evaluate the effects of butamirate and dextromethorphan on capsaicin induced cough in healthy volunteers. BrJ Clin Pharmacol ; Antitussive activity of sigma-1 receptor agonists in the guinea-pig. Br J Pharmacol ; A new method for evaluating antitussives in cats using an electrode-cannula.

Eur J Pharmacol ; Lejeune J, Weibel MA. Comparison of 2 antitussive agents in pediatrics butamirate citrate in drinkable solution and zipeprol syrup. Rev Med Suisse Romande ; Germouty J, Weibel MA. Clinical comparison of butamirate citrate with a codeine-based antitussive agent. Charpin J, Weibel MA. Comparative evaluation of the antitussive activity of butamirate citrate linctus versus clobutinol syrup. Respiration ; Levodropropizine for treating cough in adult and children: a meta-analysis of published studies.

Multidiscip RespirMed ; Levodropropizine effectiveness on nocturnal cough in asthmatic children. Eur Res J ; Allegra L, Bossi R. Clinical trials with the new antitussive levodropropizine in adult bronchitic patients. Arzneimittelforschung ; Efficacy and tolerability of levodropropizine and dropropizine in children with non-productive cough. J Int Med Res ; Catena E, Daffonchio L. Efficacy and tolerability of levodropropizine in adult patients with non-productive cough, comparison with dextromethorphan.

Pulm Pharmacol Ther ; Terminology, definitions, and classification of chronic pulmonary emphysema and related conditions: a report of the conclusions of a CIBA guest symposium. Malerba M, Ragnoli B. Ambroxol in the 21st century: pharmacological and clinical update.

Expert Opin Drug Metab Toxicol ; Clinical efficacy of ambroxol in the treatment of bronchial stasis. Respiration ;51 Suppl 1 Ambroxol therapy in simple chronic bronchitis: effects on subjective symptoms and ventilatory function. EurJ Respir Dis ; Chalumeau M, Duijvestijn YC. Acetylcysteine and carbocysteine for acute upper and lower respiratory tract infections in paediatric patients without chronic broncho-pulmonary disease.

Over-the-counter OTC medications for acute cough in children and adults in community settings. Comparative study of two antitussive drugs in the treatment of acute dry cough of infectious origin prospective, randomized, single blind study.

Therapie ; Alison M. Therapeutic trials in children and particularly in infants of a new expectorant cough syrup with oxomemazine base. J Med Lyon ; Chapuis, Dalmais, Belpois, etal. Its value in general medicine]. Lyon Med ; Sergysels R, Art G. A double-masked, placebo-controlled polysomnographic study of the antitussive effects of helicidine. Curr Ther Res Clin Exp ; Mainil J.

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